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  Propofol infusion syndrome ( PRIS ) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol     If  PRIS  is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated  General measures to support cardiac and renal function should be initiated promptly in patients with suspected  PRIS      Background  PRIS  = propofol infusion syndrome Refractory bradycardia and cardiovascular collapse Poorly understood mechanism Risk factors High doses of (> 4mg kg hr or 67 mcg kg min) Long duration (> 48 hrs) Younger age ( PRIS  first recognized in pediatric population) Critical illness Malnutrition Liver disease Carnitine deficiency Mitochondrial      Jan 12, 2026 ·     Propofol, known for its rapid onset, reliable patient response, and short duration of action, offers an attractive pharmacologic profile  However, concerns for propofol-related infusion syndrome ( PRIS ) have limited its use in pediatric critical care     Forgot password?    Mechanism of  PRIS  High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism     Propofol infusion syndrome ( PRIS ) is a rare propofol complication, leading to cardiac failure  It was first described in critically ill children and in adults with traumatic brain injury     Propofol-related Infusion Syndrome ( PRIS ) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:  1 day ago ·     The Power Reactor Information System ( PRIS ), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide     Propofol-related infusion syndrome ( PRIS ) is a rare but potentially fatal complication in critically ill patients  It is generally associated with high propofol doses and or prolonged propofol administration but can occur with lower doses and short exposures  49   

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